I guess if it does, it does, calculators be damned!!!
There's an IBU calculator here on the site that accounts for elevation and it definitely shows lower IBU contribution for he same amount of hops boiled for an hour. Isomerization may start at 180 but I guess the percentage of utilization increases with temp.
So... your original question of temp vs time is valid and I think the answer that you just have to calculate a different percentage of utilization. It would appear that a 1 hour whirlpool or hopstand at 180 would definitely contribute to IBU total but substantially less than a 1-hour boil at 212 or even a hotter temp in the whirlpool or hopstand. It stands to reason that if water boils at 180, it won't get to a higher temp without pressure. Utilization percentage doesn't seem to be built into the recipe calculator and requires an input, based on estimate I suppose.
I propose an experiment next time you're in CO. Try boiling a gallon of wort as usual with a measure of hops and do the same with a gallon of wort under slight pressure to raise the temp. If you could get a direct taste comparison of bitterness between the two temps, it would really illuminating.