Do you believe in the efficacy of published Water Profiles?
Like @soccerdad, I'm not entirely clear on the question. The way I interpreted the question is you are referring to the efficacy of brewing using a specific city or region's water profile. I answered "no" because you don't know what water adjustments the breweries using that water made when brewing. Also, water supplies change over time; and I'm not just talking about changes over a century or two. An example is Waukesha, Wisconsin which has high radon levels in the water they get from their wells so they will start drawing water from Lake Michigan*. Once that project is complete, the new water report for Waukesha will likely be very different from the old one.
* Because Waukesha is on the other side of the Great Lakes Watershed (meaning their rivers and ground water do not flow back to one of the Great Lakes) they need to return the water back to Lake Michigan when they are done with it and of course treat it.
I can say this on water:
My old house and my old well water certainly made very different beer than my new house! My old house had harder water and I did nothing to adjust it.
My new house has soft water - not much in it at all. I now adjust my water to achieve a balanced or malty profile - but mostly just for the desired levels of calcium etc. for yeast health.
I notice a difference in these beers compared to my old house for sure! I have also noticed a difference between beers where I adjusted the profile from balanced to malty or very malty.
However, I have never tried to replicate a specific region's water...
Thus, I cannot speak to "published water profiles" - I did not answer the poll and I am sorry if I totally derailed it with my comment. lol